AI Breakthrough: FragFold Accurately Predicts Protein Inhibitors, Unlocking New Drug Discovery Potential

Feb 26, 2025
MIT News | Massachusetts Institute of Technology
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Summary

In a groundbreaking AI breakthrough, FragFold, an innovative system leveraging AlphaFold's machine learning capabilities, accurately predicts protein fragments that can inhibit target proteins, experimentally confirming over 50% of its predictions and unlocking new frontiers in drug discovery by enabling deeper insights into protein interactions.

Key Points

  • AI system FragFold predicts protein fragments that can bind to or inhibit target proteins
  • FragFold leverages machine learning model AlphaFold to computationally identify inhibitory fragments
  • Researchers experimentally confirmed over half of FragFold's predictions, enabling new insights into protein interactions

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